Clinical medicine
20 published articles
Relationship between Purpose in Life and Executive Functions in populations with neurodegenerative conditions or preclinical cognitive risk: a scoping review
Luisa Sánchez Mejía, Paula Ospina-Lopera, Victoria Tirado, et al.
Purpose in Life (PiL) refers to a self-organizing life aim central to a person’s identity in relation to personal, occupational, and lifestyle domains. Executive Functions (EF), which support planning, reasoning and problem solving are essential to goal-directed behavior and ever…
Review articleJun 10, 2026DOI 10.61340/PURPOSELIFENDCognición espacial como marcador cognitivo temprano de la enfermedad de Alzheimer: una revisión del alcance (Scoping review)
Wendy´K Babilonia, Juan Pablo Sánchez Escudero
Introducción: La Cognición Espacial (CE) depende de una red funcional que involucra diversas regiones cerebrales, entre ellas el hipocampo y la corteza entorrinal, regiones que se ven afectadas de manera temprana en la enfermedad de Alzheimer (EA). Aunque diversos estudios han ex…
Research articleMay 21, 2026DOI 10.61340/COGNESPAADCrainio non-invasive intracranial pressure monitor for traumatic brain injury: feasibility study
Maria Roldan, Chadi Hajj, Christopher Uff, et al.
Traumatic brain injury (TBI) affects approximately 70 million individuals annually worldwide, often leading to significant morbidity and mortality. Intracranial pressure (ICP) monitoring plays a vital role in managing severe TBI and other conditions associated with intracranial h…
Methods articleDec 10, 2025DOI 10.61340/CRAINIOFSREELIN-COLBOS (H3447R) in Colombian oldest-old individuals, a case series
Daniel Vásquez, David Aguillón, Paula Pérez-Corredor, et al.
We previously identified REELIN-COLBOS (RELN H3447R) and APOE Christchurch (APOE R136S) as candidate gene variants associated with protection against dementia in cases at the highest risk of Alzheimer’s Disease (AD) due to the PSEN1 E280A mutation in Colombia. Here, we examined t…
Research articleDec 3, 2025DOI 10.61340/RCCOOPPoblación de los más longevos en Colombia: un estudio piloto
Daniel Vasquez, Liliana Hincapie, Yesica Zuluaga, et al.
Antecedentes: La población de adultos mayores en el mundo y en Colombia está creciendo. La población mayor de 80 años presenta necesidades y características distintas a las de los adultos mayores más jóvenes. Sin embargo, la información disponible sobre estos en Colombia es limit…
Research articleSep 3, 2025DOI 10.61340/OOPCPS01From big data to personalized medicine: bioinformatics perspectives and challenges
Ilya Ioshikhes
The rapid accumulation of various types of -omics data is opening new vistas for the development of novel therapeutic approaches grounded in big data. Particularly, personalized medicine stands out as one of the most promising goals. However, it faces significant logical and math…
EditorialJul 22, 2025DOI 10.61340/FBDTPM¿Qué hay detrás del signo del orador?
Sanat Phatak, Pranav Mahadevkar, Jennifer L. Ingram, et al.
Contrastamos dos pacientes, uno con diabetes tipo 2 y otro con esclerosis sistémica (ES), que presentaban una restricción severa de las articulaciones de las manos. A pesar de hallazgos clínicos similares, la resonancia magnética reveló tenosinovitis inflamatoria en el caso de la…
Case reportJul 16, 2025DOI 10.61340/WIAPS02What is in a prayer sign?
Sanat Phatak, Pranav Mahadevkar, Jennifer L. Ingram, et al.
We juxtapose two patients—one with type 2 diabetes and one with systemic sclerosis (SSc)—who both exhibited severe hand joint restriction. Despite similar clinical findings, MRI revealed inflammatory tenosynovitis in SSc versus non-inflammatory fibrotic changes in diabetes. This…
Research articleJun 30, 2025DOI 10.61340/WIAPS01The use of aqueous humor cfDNA for low-pass whole genome sequencing as a clinical test to identify intraocular retinoblastoma recurrence
Douglas Chigane, Drishti Pandya, Brianne Brown, et al.
Objective: Patients with retinoblastoma (RB) require serial examinations under anesthesia (EUA) to assess for response to treatment and disease recurrence. Monitoring for disease recurrence is complicated in patients with loss of fundoscopic view, such as with vitreous hemorrhage…
Case reportJun 3, 2025DOI 10.61340/UAHCTIRBROldest-old population in Colombia: A pilot study
Daniel Vasquez, Liliana Hincapie, Yesica Zuluaga, et al.
Background: The population of elderly people in the world and in Colombia is growing. Thus, the population over 80 years of age has different needs and characteristics than the population of older people under 80 years of age. However, the information available for Colombia is li…
Research articleMay 21, 2025DOI 10.61340/OOPCPSRetinal cell death is primarily caspase-dependent in vitro and in a mouse model of chloroquine-induced acute retinal toxicity
Dhanesh Amarnani, Eric J. Kim, Brandon V. Duffy, et al.
Purpose: To investigate the mechanism of chloroquine-induced cell death in vitro in adult human retinal pigmented epithelial (ARPE-19) cells and murine 661W photoreceptor-derived cells and to evaluate a mouse model of acute chloroquine-induced retinal toxicity. Methods: Human R…
Research articleMay 1, 2025DOI 10.61340/RCDPCDA Case of Keratomalacia in Severe Vitamin A Deficiency
Jonathan W. Deck, Athena Cohen, Joseph Raevis, et al.
Vitamin A is a lipid-soluble vitamin essential for vision, playing a critical role in the function and health of the retina and cornea. While vitamin A deficiency is a common global health issue, it is relatively rare in the United States, typically occurring in the context of ma…
Case reportFeb 26, 2025DOI 10.61340/CKSVAD1701El papel del equipo de enfermería del Grupo de Neurociencias de Antioquia (GNA) en la ejecución del ensayo clínico de prevención para la enfermedad de Alzheimer familiar precoz en Colombia
Lucía Madrigal Zapata, Claudia Cristina Madrigal Mesa, Érika Gallego Álvarez, et al.
El presente artículo tiene el objetivo de describir la experiencia del equipo de enfermería del Grupo de Neurociencias de Antioquia (GNA) en la atención a participantes del ensayo clínico Alzheimer’s Prevention Initiative (API) Colombia y resaltar la dimensión profesional del áre…
Research articleFeb 20, 2025DOI 10.61340/PEEGNAThe role of the nursing team of the Neurosciences Group of Antioquia (GNA) in the execution of the prevention clinical trial for early-onset familial Alzheimer’s disease in Colombia
Lucía Madrigal Zapata, Claudia Cristina Madrigal Mesa, Érika Gallego Álvarez, et al.
This paper aims to describe the experience of the nursing team at the Neurosciences Group of Antioquia (GNA) in providing care to participants in the Alzheimer’s Prevention Initiative (API) clinical trial in Colombia, highlighting the professional role of healthcare providers fro…
Research articleFeb 17, 2025DOI 10.61340/RNTNGAFrom Ancient Rituals to Modern Rhinoplasty: A Historical Evolution of Nasal Reconstruction
Jonathan W. Deck, Samantha Morin, Bryan S. Torres, et al.
Background and aims: As surgical practices continue to evolve, the origins of these techniques and their respective indications are often lost over time, while in other cases they remain fundamental to modern utility. Rhinoplasty is a prime example of an operative intervention th…
Review articleDec 3, 2024DOI 10.61340/FARMR6083A Novel Approach to the Levothyroxine Absorption Test Using Only Two Free T4 Measurements
Carlos A. Builes-Barrera, María Carolina Fragozo-Ramos, Carlos E. Builes-Montaño
Background and aims: Levothyroxine (LT4) pseudomalabsorption is a factitious disorder. The LT4 absorption test is a non-invasive method for distinguishing true LT4 malabsorption from LT4 pseudomalabsorption in people with hypothyroidism. This study aimed to evaluate a simplified…
Research articleOct 3, 2024DOI 10.61340/HFQG5777Deterioro inusual y predominante de la memoria en paciente en etapa temprana de CADASIL: Cuatro años de seguimiento longitudinal a una demencia vascular hereditaria
Carolina Ospina, Dorothee Schoemaker, Lina Marcela Velilla, et al.
Introducción: Los déficits en las funciones ejecutivas y la velocidad de procesamiento han sido considerados tradicionalmente como la manifestación principal de las contribuciones vasculares al deterioro cognitivo y la demencia. Este estudio de caso describe la progresión longitu…
Case reportJul 15, 2024DOI 10.61340/AVMB3899Unusual Predominant Memory Decline in an Early-Stage CADASIL Patient: A Four-Year Longitudinal Follow-Up of Hereditary Vascular Dementia
Carolina Ospina, Dorothee Schoemaker, Lina Marcela Velilla, et al.
Introduction: Deficits in executive function and processing speed have traditionally been viewed as the chief cognitive manifestation of vascular contributions to cognitive impairment and dementia. This case study describes the longitudinal progression of cognitive symptoms in a…
Case reportJun 24, 2024DOI 10.61340/YBYK7793What is missing: “Prevent and cure Alzheimer's”
Francisco Lopera
To control the global epidemic of dementia, multidisciplinary guidelines should be directed at the healthy general population. The PREVENTION strategy should be accompanied by a strong PROMOTION strategy for healthy and successful aging that prevents the development of mild cogni…
Research articleJan 29, 2024DOI 10.61340/FJXW5132Lo que nos falta: “Prevenir y curar el Alzheimer”
Francisco Lopera
Para controlar la epidemia mundial de demencia, se deben dirigir pautas multidisciplinarias a la población general saludable. La estrategia de PREVENCIÓN debe ir acompañada de una fuerte estrategia de PROMOCIÓN para un envejecimiento saludable y exitoso que prevenga el desarrollo…
EditorialJan 29, 2024DOI 10.61340/RCNI4859